During her eighteenth year, Alba enrolls in the university and falls in love with Miguel. Miguel is also a student and a revolutionary. They do not know that their families are already intertwined and that Miguel was present at Alba's birth. Out of love for Miguel, Alba becomes involved in revolutionary politics. She joins Miguel, Professor Sebastian Gomez, and a group of students in an occupation of the university. Just when Alba begins to doubt her interest in the cause, she becomes quite ill and is forced to leave before the end of the protest. The policeman who escorts her out is Esteban Garcia. He reveals to Miguel that Alba is Senator Trueba's granddaughter. Esteban Garcia also reminds Alba of her fourteenth birthday when he came to the house on business with her father and molested her a second time, simultaneously kissing and strangling her.
Miguel quickly decides that it is pointless to be upset at Alba for her grandfather's politics. They become consumed by their love for one another and spend an entire year devoted to making love as often as possible. After that, they return to their other occupations and continue their relationship. They do not move in together because Miguel realizes that he will some day have to devote himself to the revolution much more deeply than Alba will be ready for.
Years before, Jaime accidentally met the Candidate for the Socialist party, on a medical call. Over the years, when the Candidate ran for president unsuccessfully every year, they developed a deep friendship. Now the Candidate tells Jaime that this year the socialists will win the elections. No one aside from Jaime believes him. Miguel adds that even if the socialists come to power, little will change. The campaign is particularly nasty, and in protest of the Conservative parties' tactics, Jaime moves out of the family house and into the hospital where he works.
Jaime is the only person Alba tells of her relationship with Miguel. Jaime experiences some paternal jealousy over the relationship but keeps Alba's relationship a secret. Then Alba and Miguel come to Jaime to ask him as a doctor to look at Miguel's sick sister. When he arrives to examine her, Jaime recognizes Amanda. He only tells Miguel and Alba that they knew each other long ago; it has in fact been twenty years. Amanda is so strung out that she is almost dead. She does not recognize Jaime. Jaime prescribes hospitalization and detoxification.
Each chapter up until now has picked up fairly close in time to when the previous chapter ended. It is not clear exactly how many years chapter ten covers, but at least several years elapse between the end of chapter ten and the beginning of chapter eleven. The chapter itself spans 2–3 years. It is one of the few in which Esteban's first person narrative voice is not present.
Chance or strange twists of fate recur repeatedly in The House of the Spirits. Alba's encounter with Miguel is no different. The two meet in the university cafeteria. Although neither one remembers the first encounter, on the day of Alba's birth, something immediately draws them to one another. Like her mother and her grandmother before her, Alba seems fated from a very young age to be with this particular man.