Aaron Burr and Alexander Hamilton
Hamilton regarded Burr as a moral void interested only in social climbing, rather than the improvement of the country. When Burr ran for President in 1800, Hamilton said, "nope" and used his influence to thwart Burr's chances. When Burr then ran for New York governor, Hamilton said, "nuh uh" and blocked him again. Smoke blew out of Burr's ears, and he challenged Hamilton to a very ill-advised duel in which Hamilton was killed, and Burr's reputation was ruined forever.