The Invisible Man by Ralph Ellison
Ellison's masterpiece was deeply informed by the cultural atmosphere of the 1920s and 1930s in New York. In many ways, it's the anti-Gatsby: the story of a culture that worships wealth, excess, and social climbing, told not from the outside looking in. The narrator isn't literally invisible, but he's black in the United States during the Jazz Age, so he may as well be. The novel has been called the "Kevin Bacon of American literature" because it basically weaves together every important theme in the American literary canon, separating it from every other major work by only a few degrees.