Hacking DNA With... Something?
The Movie: Aldrich Killian develops a new technology called Extremis, which can apparently reprogram the human genome. As Marvel's Kevin Feige puts it, Extremis is "something that taps into human DNA and is able to reprogram it and regenerate limbs and enhance strength and cure wounds."
Real Life: Gee, you want to vague it up a little more there? He literally just says that it is "something." That really narrows it down. So let's try to figure this out: we know it is administered by injection so it's not gene therapy. It also needs to be updated often, so it's not permanent genetic remodeling, which might be possible with bio-nanotechnology one day (emphasis on "might"). It also performs many functions at once and has the side effect of allowing people to control their own thermostat. So let's just get it over with and call it what it is: magic. Instead of giving a presentation, Aldrich should have just waltzed in to Pepper Potts' office, chucked some magic beans at her, and spontaneously combusted. It would have made as much sense.