Antipholus of Syracuse
- The twin brother of Antipholus of Ephesus and the son of Egeon; he has been traveling the world with his slave, Dromio of Syracuse, trying to find his long-lost brother and mother.
Antipholus of Ephesus
- The twin brother of Antipholus of Syracuse and the son of Egeon; he is a well-respected merchant in Ephesus and Adriana's husband.
Dromio of Syracuse
- The bumbling, comical slave of Antipholus of Syracuse. He is the twin brother of Dromio of Ephesus.
Dromio of Ephesus
- The bumbling, comical slave of Antipholus of Ephesus. He is the Syracusan Dromio's twin brother.
- The wife of Antipholus of Ephesus, she is a fierce, jealous woman.
- Adriana's unmarried sister and the object of Antipholus of Syracuse's affections.
- The Duke of Ephesus; a just but merciful ruler.
- A Syracusan merchant, husband of the Abbess (Emilia), and the father of the two Antipholi. He is, like his Syracusan son, in search of the missing half of his family; he has been sentenced to death as the play begins.
- Emilia, the long-lost wife of Egeon and the mother of the two Antipholi.
- A merchant in Syracuse.
- A goldsmith in Syracuse and a friend to Antipholus of Ephesus.
- An Ephesian friend of Antipholus of Syracuse.
- A tradesman to whom Angelo is in debt.
- A schoolteacher, conjurer, and would-be exorcist.
- Also called Nell. Antipholus of Ephesus' prodigiously fat maid and Dromio of Ephesus' wife.
- An expensive prostitute and friend of Antipholus of Ephesus.