In this speech Vladimir also declares that at this point, "all mankind is us, whether we like it or not." This continues the theme of Vladimir and Estragon's representation of mankind as a whole and shows that Vladimir is himself aware of this comparison. Estragon also illustrates the parallel between the two men and the rest of humanity when he tells Vladimir that "billions" of people can also claim that they have kept their appointment. In this case Vladimir attempts to distinguish them from the rest of mankind, but Estragon insists that they are actually the same.
Another biblical allusion is presented here through the comparison of Pozzo and Lucky to Cain and Abel. However, when Pozzo responds to the names Cain and Abel, Estragon decides that "he's all humanity." This suggestion indicates once more that the characters in the play represent the human race as a whole.
Vladimir's need of Estragon's help in order to get up is somewhat of a role reversal. For a brief exchange, Estragon holds the power in the relationship as Vladimir calls to him for help. However, when Estragon does finally stretch out his hand to help Vladimir up, he only falls himself. This seems to indicate that Estragon does not belong in this position of power and responsibility and cannot act to fulfill it.