Problem : Please draw the most stable conformations of the following molecules as 3D chair representations. When relevant, please indicate side chain conformations as well.
Problem : The isomers of dimethylcyclohexane present an interesting opportunity to examine steric interactions in cyclic compounds. Please rationalize the following thermodynamic data by (i) drawing out both chair conformations of each compound, and (ii) indicating the presence of any unfavorable steric interactions.
Problem : Please circle the more stable compound in each of the following pairs and give a brief rationale for your choice:
Problem : Monosubstituted cyclohexanes always prefer to orient their substituent in an equatorial position in order to minimize 1,3-diaxial interactions. Consider the following free energy data:
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