Of Mice and Men teaches a grim lesson about the nature of human existence. Nearly all of the characters, including George, Lennie, Candy, Crooks, and Curley’s wife, admit, at one time or another, to having a profound sense of loneliness and isolation. Each desires the comfort of a friend, but will settle for the attentive ear of a stranger. Curley’s wife admits to Candy, Crooks, and Lennie that she is unhappily married, and Crooks tells Lennie that life is no good without a companion to turn to in times of confusion and need. The characters are rendered helpless by their isolation, and yet, even at their weakest, they seek to destroy those who are even weaker than they. Perhaps the most powerful example of this cruel tendency is when Crooks criticizes Lennie’s dream of the farm and his dependence on George. Having just admitted his own vulnerabilities—he is a black man with a crooked back who longs for companionship—Crooks zeroes in on Lennie’s own weaknesses.

In scenes such as this one, Steinbeck records a profound human truth: oppression does not come only from the hands of the strong or the powerful. Crooks seems at his strongest when he has nearly reduced Lennie to tears for fear that something bad has happened to George, just as Curley’s wife feels most powerful when she threatens to have Crooks lynched. The novel suggests that the most visible kind of strength, that used to oppress others, is itself born of weakness.

One of the reasons that the tragic end of George and Lennie’s friendship has such a profound impact is that one senses that the friends have, by the end of the novel, lost a dream larger than themselves. The farm on which George and Lennie plan to live—a place that no one ever reaches—has a magnetic quality, as Crooks points out. After hearing a description of only a few sentences, Candy is completely drawn in by its magic. Crooks has witnessed countless men fall under the same silly spell, and still he cannot help but ask Lennie if he can have a patch of garden to hoe there. The men in Of Mice and Men desire to come together in a way that would allow them to be like brothers to one another. That is, they want to live with one another’s best interests in mind, to protect each other, and to know that there is someone in the world dedicated to protecting them. Given the harsh, lonely conditions under which these men live, it should come as no surprise that they idealize friendships between men in such a way.

Ultimately, however, the world is too harsh and predatory a place to sustain such relationships. Lennie and George, who come closest to achieving this ideal of brotherhood, are forced to separate tragically. With this, a rare friendship vanishes, but the rest of the world—represented by Curley and Carlson, who watch George stumble away with grief from his friend’s dead body—fails to acknowledge or appreciate it.

Most of the characters in Of Mice and Men admit, at one point or another, to dreaming of a different life. Before her death, Curley’s wife confesses her desire to be a movie star. Crooks, bitter as he is, allows himself the pleasant fantasy of hoeing a patch of garden on Lennie’s farm one day, and Candy latches on desperately to George’s vision of owning a couple of acres. Before the action of the novel begins, circumstances have robbed most of the characters of these wishes. Curley’s wife, for instance, has resigned herself to an unfulfilling marriage. What makes all of these dreams typically American is that the dreamers wish for untarnished happiness, for the freedom to follow their own desires. George and Lennie’s dream of owning a farm, which would enable them to sustain themselves, and, most important, offer them protection from an inhospitable world, represents a prototypically American ideal. Their journey, which awakens George to the impossibility of this dream, sadly proves that the bitter Crooks is right: such paradises of freedom, contentment, and safety are not to be found in this world.

The portrayal of women in Of Mice and Men is limited and unflattering. We learn early on that Lennie and George are on the run from the previous ranch where they worked, due to encountering trouble there with a woman. Misunderstanding Lennie’s love of soft things, a woman accused him of rape for touching her dress. George berates Lennie for his behavior, but is convinced that women are always the cause of such trouble. Their enticing sexuality, he believes, tempts men to behave in ways they would otherwise not.

A visit to the “flophouse” (a cheap hotel, or brothel) is enough of women for George, and he has no desire for a female companion or wife. Curley’s wife, the only woman to appear in Of Mice and Men, seems initially to support George’s view of marriage. Dissatisfied with her marriage to a brutish man and bored with life on the ranch, she is constantly looking for excitement or trouble. In one of her more revealing moments, she threatens to have the black stable-hand lynched if he complains about her to the boss. Her insistence on flirting with Lennie seals her unfortunate fate. Although Steinbeck does, finally, offer a sympathetic view of Curley’s wife by allowing her to voice her unhappiness and her own dream for a better life, women have no place in the author’s idealized vision of a world structured around the brotherly bonds of men.

Many of the characters admit to suffering from profound loneliness. George sets the tone for these confessions early in the novel when he reminds Lennie that the life of a ranch-hand is among the loneliest of lives. Men like George who migrate from farm to farm rarely have anyone to look to for companionship and protection. As the story develops, Candy, Crooks, and Curley’s wife all confess their deep loneliness. The fact that they admit to complete strangers their fear of being cast off shows their desperation. In a world without friends to confide in, strangers will have to do. Each of these characters searches for a friend, someone to help them measure the world, as Crooks says. In the end, however, companionship of his kind seems unattainable. For George, the hope of such companionship dies with Lennie, and true to his original estimation, he will go through life alone.

Steinbeck explores different types of strength and weakness throughout the novel. The first, and most obvious, is physical strength. As the novel opens, Steinbeck shows how Lennie possesses physical strength beyond his control, as when he cannot help killing the mice. Great physical strength is, like money, quite valuable to men in George and Lennie’s circumstances. Curley, as a symbol of authority on the ranch and a champion boxer, makes this clear immediately by using his brutish strength and violent temper to intimidate the men and his wife.

Physical strength is not the only force that oppresses the men in the novel. It is the rigid, predatory human tendencies, not Curley, that defeat Lennie and George in the end. Lennie’s physical size and strength prove powerless; in the face of these universal laws, he is utterly defenseless and therefore disposable.

The farm that George constantly describes to Lennie, those few acres of land on which they will grow their own food and tend their own livestock, is one of the most powerful symbols in the book. It seduces not only the other characters but also the reader, who, like the men, wants to believe in the possibility of the free, idyllic life it promises. Candy is immediately drawn in by the dream, and even the cynical Crooks hopes that Lennie and George will let him live there too. A paradise for men who want to be masters of their own lives, the farm represents the possibility of freedom, self-reliance, and protection from the cruelties of the world.

Lennie’s puppy is one of several symbols that represent the victory of the strong over the weak. Lennie kills the puppy accidentally, as he has killed many mice before, by virtue of his failure to recognize his own strength. Although no other character can match Lennie’s physical strength, the huge Lennie will soon meet a fate similar to that of his small puppy. Like an innocent animal, Lennie is unaware of the vicious, predatory powers that surround him.

In the world Of Mice and Men describes, Candy’s dog represents the fate awaiting anyone who has outlived his or her purpose. Once a fine sheepdog, useful on the ranch, Candy’s mutt is now debilitated by age. Candy’s sentimental attachment to the animal—his plea that Carlson let the dog live for no other reason than that Candy raised it from a puppy—means nothing at all on the ranch. Although Carlson promises to kill the dog painlessly, his insistence that the old animal must die supports a cruel natural law that the strong will dispose of the weak. Candy internalizes this lesson, for he fears that he himself is nearing an age when he will no longer be useful at the ranch, and therefore no longer welcome.