The treatment of the weakest and most vulnerable among us defines what it means to be human. When the novel begins in 1964, the American medical establishment had not yet accorded full rights to people with Down syndrome and routinely warehoused them away from society. Set in this historical context, the book dramatizes the choice a doctor makes when his wife gives birth to twins, one a healthy boy, the other a girl with Down syndrome. The story pits the strategies of fear against the creativity and courage of love.

The doctor, David Henry, sets the plot in motion when he reacts to protect the status quo rather than embrace change. Under the cover of convention, he rejects his newborn daughter and strategizes a course that will completely eliminate her from his life. He enlists his colleague, nurse Caroline Gill, as a co-conspirator to secretly deliver the baby to an institution for the handicapped where she will live out her life. Circumstances converge to allow him to plant the belief that his daughter, Phoebe, died at birth. However, his limited worldview doesn’t anticipate Caroline’s altruism. Her practiced clinical eye rejects the inhumane facility. She defies David’s expectations and activates her own vision for the newborn girl by leaving town to raise Phoebe on her own. The narrative depicts the effects of their choices, alternately following the protagonist, David Henry, and the antagonist, Caroline Gill. Geographic locations emphasize their divergent paths. David, Norah, and their son Paul live in an affluent area of Lexington, Kentucky. Caroline and Phoebe relocate to a working-class neighborhood of Pittsburgh, Pennsylvania. The omniscient narrator tells the story from each character’s point of view.

In Lexington, Dr. David Henry issues a death certificate and has a mock burial for Phoebe. Norah Henry bears the full brunt of the deception, navigating the loss alone in grief and horror. Committed to her husband and devoted to her son Paul, Norah struggles against her descent into depression and with the help of her sister Bree emerges into acceptance. David’s guilt dogs him, and the longing for his missing daughter haunts him, but unresolved issues from his childhood drive him to isolation. He alienates Paul, a classical guitar prodigy who seeks approval for a career in music but receives opposition from his fearful father. In Pittsburgh, Phoebe flourishes under Caroline’s diligent care that includes advocacy for those with Down syndrome. Caroline’s passion for change builds a community around her, a contrast to her solitary existence in Lexington. Phoebe grows into an adult woman with a job, music interests, and a marriage engagement, all developments unheard of in an institution.

In the climax of the story, eighteen years after the twins’ births, David and Caroline cross paths and the deception implodes. They each confront their culpability in the crime. Caroline realizes that her conviction of an intimate connection with David was a fantasy and she is now emotionally free to move on, fully committing to her life with Al, the man whom she met the night she brought Phoebe home. David contemplates suicide and goes back to his childhood home in West Virginia, where he comes to terms with his grief and resentment about the death of his sister June and accepts that he did wrong by rejecting his daughter. There he finds a pregnant teen, Rosemary, who’s been hiding in the house to protect her unborn baby. Not only does David take Rosemary under his wing, having her live with his family for some time and then, years later, sharing a duplex with her and her son, but he also sets up trust funds for Phoebe and Rosemary’s son to pay out at his death.

When David returns to Lexington after visiting his childhood home, he gives Paul the support he’s withheld and ends his marriage. Something about meeting Rosemary and revealing his secret to her has set him free, and he’s finally able to move forward in his life. He can’t bring himself to tell Norah that Phoebe is alive and well, and he takes his secret to the grave when he suddenly dies of a heart attack.

In the denouement, Caroline travels from Pittsburgh to Lexington to repair the past. She confesses to Norah her part in her daughter’s disappearance for twenty-five years. Norah long ago learned to move beyond David’s wrongs. She resolves to integrate Phoebe into her life from this point forward. Paul and Phoebe finally meet at twenty-five years of age. Paul’s talent and Julliard training have propelled him into an international performance career, defying David’s expectations of failure. Phoebe’s kind disposition and joy in life have found a kindred spirit in her fiancé, and David’s trust fund ensures her financial security. The book ends with Phoebe and Paul standing at David’s grave. Despite all the heartbreak David caused, Phoebe and Paul mourn his passing with a hymn, their shared love of music a final tribute to their father, a clear message of forgiveness and redemption.