Get Out begins with a brief and violent scene where a Black man is subdued, pulled into a car, and kidnapped as he walks alone at night through a quiet suburb. The song “Run Rabbit Run” plays on the radio of the car that snatches him. The movie’s perspective then switches to the storyline of its main characters. Chris Washington (played by Daniel Kaluuya), a young Black photographer, prepares for a weekend trip with his white girlfriend, Rose Armitage (played by Allison Williams). He and Rose are driving to meet her family at their estate in Upstate New York. He expresses concern about her parents not knowing he is Black, but Rose enthusiastically reassures him that they are not racist. Chris calls his friend Rod, a TSA agent, and Rod, Chris and Rose all joke about Rose choosing to date the wrong friend. Chris tries to light a cigarette, but Rose smacks it out of his hand and out of the window. During Chris and Rose’s drive, they hit and kill a deer, and a police officer arrives. The officer asks for Chris’s license, even though he was not driving. Rose angrily defends Chris and accuses the cop of racially profiling him, and the officer lets them go.  

They arrive at the secluded Armitage estate, where Rose’s parents, neurosurgeon Dean (played by Bradley Whitford) and hypnotherapist Missy (played by Catherine Keener), welcome Chris. Dean shows Chris around and acknowledges the uncomfortable optics of his white family having Black servants, but explains that Georgina, their maid, and Walter, their groundskeeper, chose to stay on after caring for his parents. Chris notices that both Georgina and Walter are behaving strangely. Dean sees Chris fidgeting and offers to have Missy hypnotize him to help him quit smoking, but Chris refuses. At dinner, Rose’s brother Jeremy tells embarrassing stories about Rose and her ex-boyfriends. When Chris mentions that he used to practice judo, Jeremy makes a racially charged comment about Black men's physical strength, suggesting Chris shouldn’t have quit, and even going so far as to ask if he can practice a jiu-jitsu move on Chris. 

When they go to bed, Rose apologizes for her family’s micro-aggressions and complains to Chris about her family’s embarrassing racism. Chris brushes it off. Rose goes to sleep, but Chris can’t drift off. He sneaks outside for a smoke and is terrified when he sees Walter running directly toward him at high speed, narrowly missing him as he veers into a sharp turn. In the distance, he also sees Georgina standing in the driveway. Missy catches him smoking and makes him come inside. Inside, Missy invites Chris to sit with her and asks about his mother’s death. He recalls how she was struck in a hit-and-run when he was a child and died because he did not call 911 quickly enough. Missy speaks aggressively to Chris about his role in his mother’s death as she stirs her tea, hypnotizing him, and Chris suddenly finds himself unable to move. He falls into a trance, sinking into a dark void that Missy calls the “Sunken Place.” He wakes up in bed abruptly, assuming the whole thing was a nightmare, but he realizes that he also no longer has a desire to smoke.  

The next day, guests arrive for an annual gathering at the Armitage home. Almost all of the attendees are wealthy white people who make uncomfortable comments about Black people under the guise of giving compliments. They also repeatedly express admiration for Black men’s bodies, making Chris and Rose cringe. Chris notices another Black man at the party, who introduces himself as Logan King. Chris thinks Logan seems familiar, and notices that Logan behaves stiffly, dresses in an old-fashioned way, and acts as if he’s far older than he appears, an impression that’s further emphasized when his much older white wife Philomena joins the conversation. Chris is initially happy to see Logan but feels confused and awkward when the interaction ends. He wanders outside to a gazebo, where he meets a blind art dealer named Jim Hudson. Jim tells Chris that he is a huge fan of his work (explaining that his assistant has described Chris’s photos to him) and says that he’d always wanted to be able to take beautiful photographs, but didn’t have Chris’s talent. Chris retreats upstairs to find his phone unplugged. He suspects Georgina did it because she disapproves of him dating Rose. Chris calls Rod and tells him about the weirdness of the visit and his suspicions that Missy hypnotized him. Rod immediately suspects foul play and warns Chris to leave.  

Georgina walks into the room and Chris confronts her about unplugging his phone charger. She and Chris have a frightening interaction where she smiles and weeps while telling him the Armitages are good to her and Walter. When Chris returns downstairs, he tries to surreptitiously take a picture of Logan. However, his camera flash causes Logan’s nose to bleed. Logan suddenly panics, yelling at Chris to “get out!” and struggling against the rush of guests who try to subdue him. Dean and Missy restrain Logan and take him away, and Dean later explains that the camera flash caused Logan to have a seizure. Chris and Rose go for a walk, and Chris tells Rose that he’s had enough and wants to go home. Meanwhile, unbeknownst to Chris, all the party guests participate in a silent auction, where, chillingly, a large photo of Chris seems to imply that Chris himself is the prize. Jim Hudson has the highest bid, and wins. 

That night, Chris and Rose sit by the lake having a heart-to-heart. He explains to Rose that he always felt guilty for his mother’s death, as it might have been prevented if he had called 911 sooner. Rose agrees to leave her parents’ house with him, and the two wander back inside. Unable to shake the idea that he knows Logan from somewhere, Chris texts Rod the photo he took.  Rod, alarmed, texts back immediately and tells Chris that they do know him: the man in the photo is actually Andre Hayworth, a Black man whose picture was recently in the news after he mysteriously disappeared (this is the abduction show in the very first scene in the film). The fact that Andre, now inexplicably going by the name Logan, was at the party with a much older white woman makes Rod think he’s been made into a sex slave by the white families in Rose’s parents’ friend group. Rod is urging Chris to get out of the house when their connection gets cut off. As Chris is packing, he finds a box full of photos of Rose with Walter, Georgina, and several other Black men Chris doesn’t know. Chris decides to leave immediately.  

When he gets downstairs, Dean is waiting for him by the fireplace, holding forth about how humans all have godlike potential, and Jeremy is menacingly spinning a lacrosse stick in front of the door. Chris asks Rose to get their car keys, and she appears to frantically search for them. Chris gets more and more agitated and panicked, until eventually Rose tells Chris she can’t give him the keys, and it becomes clear that she was never actually looking for them, only pretending to in order to stall Chris. As Chris tries to grab the keys and escape, Missy taps her spoon against her teacup, and Chris immediately loses control, falling into Missy’s hypnosis. Missy tells Jeremy and Dean to bring him downstairs, and as he’s carried out of the room, Rose quietly tells Chris that he was “one of her favorites.”  

Chris wakes up strapped to a chair in the Armitage basement. A video plays on a TV in front of him, where Rose’s grandfather Roman explains that his family, who belong to a cult called the Order of Coagula, have developed a groundbreaking medical procedure. Through this process, the brains of wealthy white people are “transmuted” into Black bodies, allowing the white people to live longer while the Black host consciousness remains trapped in the Sunken Place. Chris passes out again after the video switches to a recording of Missy stirring tea. Meanwhile, Rod goes to a police station and meets with Detective Latoya to report Chris's disappearance. He tells her that he suspects that Chris has been abducted by white people to be used as a sex slave and tries to explain about Andre, but Latoya and her colleagues laugh uproariously at his theory. Later, Rod calls Rose to investigate further. Rose lies, pretending to be confused; according to her, Chris has already left and should be back home. Rod doesn’t believe her, especially when she accuses him of being in love with her himself and being jealous of Chris. He turns on a recording device to try and catch Rose out. Rose tells him she knows he wants to sleep with her. Rod hangs up, but not before making sure he’s recorded their conversation for proof she’s lying. 

Meanwhile, Chris wakes up as another video plays. Jim Hudson explains that he chose Chris for his “artistic eye,” and that the Coagula procedure will leave part of Chris’s brain intact, but Jim will control his body. Jim will live in Chris’s body while Chris remains a powerless passenger, floating forever in the Sunken Place. Chris looks down and notices that there is a hole in the arm of his chair, and some of the fluffy cotton stuffing has started to come out. Jeremy enters the room to prepare Chris for surgery. In another room, Dean is starting to cut into Jim Hudson’s head as he lies unconscious on a surgical table. When Jeremy unstraps Chris, Chris attacks him with a pool ball, knocking him out cold. Chris then pulls cotton from his ears, revealing to the viewer that he secretly took it from the chair and stuffed his ears in order to protect himself from the hypnotic sounds of Missy’s spoon. Chris hears Dean calling out for Jeremy and sneaks up on him, killing him by impaling him with the antlers from the deer’s head hanging over the TV. 

Chris runs upstairs, knocking over a candle in his rush, which quickly sets the house ablaze. He grabs his phone from a table as he passes. Missy tries to use her teacup to hypnotize him again, but he grabs the cup and smashes it. Missy, infuriated, stabs him in the hand with a knife, but he pulls it out and stabs her, eventually killing her. As all of this is happening, Rose lies on her bed upstairs listening to music, eating cereal, and scrolling through photos of Black athletes online. Jeremy tries to stop Chris from escaping by tackling him, but Chris stabs him in the leg and stomps on his head to subdue him. Chris jumps into a car in the driveway, and the audience sees that there’s a mask sitting on the passenger seat. It’s the same one that Andre’s kidnapper, whom they now know was Jeremy, was wearing in the first scene. The same song, “Run Rabbit Run,” plays over the car stereo as Chris peels off from the house.  

Chris tries to call the police, but while he’s distracted, he accidentally hits Georgina with the car. Haunted by memories of his mother’s death and unwilling to leave Georgina behind, he carries her into the car. As they drive off, Georgina suddenly attacks him—it's now clear she’s been possessed by Rose’s grandmother, a fact revealed when Rose chases after them, shouting Georgina’s real name and firing a gun. The car crashes, killing Georgina. Rose shoots at the wreck and sends Walter to retrieve Chris. Remembering how Logan briefly broke free of the Coagula conditioning after a camera flash, Chris uses his phone to take a picture of Walter. The flash disrupts Walter’s hypnosis just long enough for him to turn on Rose: he asks for the rifle (which she gives to him, not realizing that his hypnosis is broken), shoots her, and then turns the gun on himself. Chris begins to strangle Rose, but he can’t go through with the attack. As she lies on the ground, a police car arrives. Rose smiles, thinking Chris will be arrested for assaulting her. However, the driver is Rod, who says, "Man, I told you not to go in that house." Chris gets into Rod’s car and they drive away, leaving Rose to die in the driveway.