Problem :
What base in the following codon could be mutated to result in a nonsense
mutation?
5'-U U G-3'
If the second base is changed from a U to an A, the resulting codon is 5'-UAG-3'
which is a stop codon. Mutations that result in stop codons are called nonsense
mutations.
Problem :
Describe the difference between a base substitution mutation and an
insertion/deletion mutation.
A base substitution involves the substitution of one nucleotide for another, and
effects the coding of a single codon. An insertion/deletion mutation involves
the addition of an extra nucleotide into a sequence or the removal of a
nucleotide from a sequence. An insertion/deletion mutation can change the
entire reading frame of a genetic sequence, affecting the coding of
every
codon in that sequence.
Problem :
What type of mutation has occurred between the first and second base sequences?
1: 5'-AUGGACCAAUAU-3'
2: 5'-AUGGACAAUAU-3'
The mutation is a frameshift mutation from the deletion of a C.
