The novel's protagonist. Holmes is the famed 221b Baker Street detective with a keen eye, hawked nose, and the trademark hat and pipe. Holmes is observation and intuition personified, and though he takes a bit of a back seat to Watson in this story, we always feel his presence. It takes his legendary powers to decipher the mystifying threads of the case.
The novel's other protagonist and narrator. Dr. Watson is the stout sidekick to Holmes and longtime chronicler of the detective's adventures. In Hound, Watson tries his hand at Holmes' game, expressing his eagerness to please and impress the master by solving such a baffling case. As sidekick and apprentice to Holmes, Watson acts as a foil for Holmes' genius and as a stand-in for us, the awestruck audience.
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The late Sir Charles's nephew and closet living relative. Sir Henry is hale and hearty, described as "a small, alert, dark-eyed man about thirty years of age, very sturdily built." By the end of the story, Henry is as worn out and shell-shocked as his late uncle was before his death.
The head of the Baskerville estate. Sir Charles was a superstitious man, and terrified of the Baskerville curse and his waning health at the time of his death. Sir Charles was also a well-known philanthropist, and his plans to invest in the regions surrounding his estate make it essential that Sir Henry move to Baskerville Hall to continue his uncle's good works.
A debaucherous and shadowy Baskerville ancestor, Sir Hugo is the picture of aristocratic excess, drinking and pursuing pleasures of the flesh until it killed him.
Family friend and doctor to the Baskervilles. Mortimer is a tall, thin man who dresses sloppily but is an all-around nice guy and the executor of Charles's estate. Mortimer is also a phrenology enthusiast, and he wishes and hopes to some day have the opportunity to study Holmes' head.
A thin and bookish-looking entomologist and one-time schoolmaster, Stapleton chases butterflies and reveals his short temper only at key moments. A calm façade masks the scheming, manipulative villain that Holmes and Watson come to respect and fear.
Allegedly Stapleton's sister, this dusky Latin beauty turns out to be his wife. Eager to prevent another death but terrified of her husband, she provides enigmatic warnings to Sir Henry and Watson.
The longtime domestic help of the Baskerville clan. Earnest and eager to please, the portly Mrs. Barrymore and her gaunt husband figure as a kind of red herring for the detectives, in league with their convict brother but ultimately no more suspicious than Sir Henry.
A local young woman. Laura Lyons is the beautiful brunette daughter of "Frankland the crank," the local litigator who disowned her when she married against his will. Subsequently abandoned by her husband, the credulous Laura turns to Mr. Stapleton and Charles for help.
A murderous villain, whose crimes defy description. The convict is nonetheless humanized by his association with the Barrymores. He has a rodent-like, haggardly appearance. His only wish is to flee his persecutors in Devonshire and escape to South America.
Laura's father. Frankland is a man who likes to sue, a sort of comic relief with a chip on his shoulder about every infringement on what he sees as his rights. Villainized due to his one-time harsh treatment of Laura, Frankland is for the most part a laughable jester in the context of this story.