Will compound X undergo an E2 reaction? State your reasoning.
Compound X will not undergo an E2 reaction. It has no β-hydrogens.
Predict the product of the following E2 reaction. Assume that there is no rotation about the C-C bond.
Problem : Predict the major product of the following E2 reaction:According to Saytzeff's rule, the major product will be the most substituted alkene.
The large tert-butyl group locks the ring into its current conformation.
Using the molecular orbital theory, determine whether this molecule is a good candidate for the E2 reaction and explain why.
This conforomation of the molecule is not a good candidate for the E2 reaction. All three β-hydrogens are locked into a non-antiperiplanar conformation. Thus there will be no electron density to donate into the σ* C-Br antibond.
Let's see how the situation would change if the carbon-bromine bond had been in an axial instead of an equatorial conformation. In this case there would be antiperiplanar β-hydrogens, and E2 would be possible.