While Vladimir and Estragon stagger about pitying themselves, Pozzo and Lucky enter. Pozzo is blind and runs into Lucky, who has stopped at the sight of Vladimir and Estragon. They fall, along with all the baggage. Vladimir welcomes their arrival since it will help to pass the time. Pozzo calls for help while Vladimir and Estragon discuss asking him for another bone. Vladimir decides that they should help him, but first he and Estragon discuss how they have kept their appointment.
Pozzo continues to cry for help, and eventually Vladimir tries to assist him. However, he falls also while trying to pull up Pozzo. Estragon threatens to leave, but Vladimir begs him to help him up first, promising that they will leave together afterward. Estragon tries to help him up, but ends up falling as well.
All four men now lie on the ground, and Vladimir and Estragon begin to nap. They are woken shortly by Pozzo's shouting, and Vladimir strikes Pozzo to make him stop. Pozzo crawls away, and Vladimir and Estragon call to him. He does not respond, and Estragon decides to try other names. He calls out "Abel," and Pozzo responds by crying for help. He wonders if the other one is called Cain, but Pozzo responds to that name as well, and Estragon decides that he must be all of humanity.
Vladimir and Estragon decide to get up, which they do with ease. They help Pozzo up and hold him, and Pozzo tells them that he does not recognize them since he is blind. They tell him that it is evening, and then begin to question him about the loss of his sight. He tells them that it came upon him all of a sudden and that he has no notion of time.
Pozzo asks the men about his slave, and they tell him that Lucky seems to be sleeping. They send Estragon over to Lucky, and Estragon begins kicking Lucky. He hurts his foot and goes to sit down. Vladimir asks Pozzo if they met yesterday, but Pozzo does not remember. Pozzo prepares to leave, and Vladimir asks him to have Lucky sing or recite before they leave. However, Pozzo tells him that Lucky is dumb. They exit, and Vladimir sees them fall offstage.
Here again Vladimir seems to recognize the problem of inaction when he decides that they should help Pozzo. He becomes suddenly vehement and shouts, "Let us not waste our time in idle discourse! Let us do something, while we have the chance!" This call to action seems like an urgent rally against the trend of inaction he and Estragon have been following throughout the play; however, Vladimir still takes plenty of time to begin to help Pozzo to his feet. This suggests that, even with good intentions and resolution, the habit of inaction cannot be broken immediately.
In this speech Vladimir also declares that at this point, "all mankind is us, whether we like it or not." This continues the theme of Vladimir and Estragon's representation of mankind as a whole and shows that Vladimir is himself aware of this comparison. Estragon also illustrates the parallel between the two men and the rest of humanity when he tells Vladimir that "billions" of people can also claim that they have kept their appointment. In this case Vladimir attempts to distinguish them from the rest of mankind, but Estragon insists that they are actually the same.
Another biblical allusion is presented here through the comparison of Pozzo and Lucky to Cain and Abel. However, when Pozzo responds to the names Cain and Abel, Estragon decides that "he's all humanity." This suggestion indicates once more that the characters in the play represent the human race as a whole.
Vladimir's need of Estragon's help in order to get up is somewhat of a role reversal. For a brief exchange, Estragon holds the power in the relationship as Vladimir calls to him for help. However, when Estragon does finally stretch out his hand to help Vladimir up, he only falls himself. This seems to indicate that Estragon does not belong in this position of power and responsibility and cannot act to fulfill it.